Óragének (és a melatonin) Rékási Zoltán PTE ÁOK Anatómiai Intézet
birds mammals
Melatonin elválasztás explantált patkány tobozmirigyből normál in vitro megvilágítási ciklusban
Melatonin elválasztás explantált csirke tobozmirigyből normál in vitro megvilágítási ciklusban
MELATONIN LIGHT NORADRENERGIC and PEPTIDERGIC PATHWAYS Adrenergic and VPAC-RECEPTORS SIGNAL TRANSDUCTION CH 2 NH HO N H SEROTONIN N-acetyltransferase (AA-NAT) AcCoA CH 2 HO N H NH CH 3 O C N-ACETYLSEROTONIN hydroxyindol-o-methyltransferase (HIOMT) SAdM CH 3 O N H CH 2 MELATONIN SYNTHESIS NH C CH 3 O MELATONIN MELATONIN RELEASE
MELATONIN ? ? ? LIGHT PHOTORECEPTORS SIGNAL TRANSDUCTION CH 2 NH HO N H CLOCK (PACEMAKER) Clock-genes SEROTONIN ? N-acetyltransferase (AA-NAT) AcCoA CH 2 HO N H NH CH 3 O C N-ACETYLSEROTONIN hydroxyindol-o-methyltransferase (HIOMT) SAdM CH 3 O N H CH 2 MELATONIN SYNTHESIS NH C CH 3 O MELATONIN MELATONIN RELEASE
Four-gene core transcription-translation loop period timeless TIM PER Clock CLOCK BMAL1 Bmal1 Activation Inhibition DELAY gene expression time
Clock-genes in Drosophila and mammals PERIOD1 PERIOD PERIOD2 PERIOD3 NLS bHLH/PAS NLS NLS NLS TIMELESS CLOCK CYCLE BMAL1 Doubletime casein kinase I epsilon Cryptochrome1 Cryptochrome Cryptochrome2
Expression pattern of cAANAT, cBmal1 and cClock mRNA in chicken pineal gland
Expression pattern of cAANAT, cBmal1 and cClock mRNA in chicken retina
Expression of retinal and pineal cAANAT mRNA in chicken housed in constant darkness for 1 day or 1 week retina pineal
Expression of retinal and pineal cBmal1 mRNA in chicken housed in constant darkness for 1 day or 1 week retina pineal
Expression of retinal and pineal cAANAT mRNA in chicken housed in constant light for 1 day or 1 week
Expression of retinal and pineal cBmal1 mRNA in chicken housed in constant light for 1 day or 1 week
Model of circadian clock-work within an individual retinal or pineal photoreceptor cell Resetting the clock by light Clock Bmal1 cCry2 cCry1 cPer2 cPer3 cAANAT Output/melatonin